Structure‐activity relationships of pentamidine‐affected ion channel trafficking and dofetilide mediated rescue
British Journal of Pharmacology2013Vol. 169(6), pp. 1322–1334
Citations Over TimeTop 18% of 2013 papers
Rosanne Varkevisser, Mjc Houtman, Tobias Linder, Kakali De, HDM Beekman, Richard R. Tidwell, Adriaan P. IJzerman, Anna Stary‐Weinzinger, MA Vos, Marcel A. G. van der Heyden
Abstract
Drug-induced trafficking defects can be minimized if certain chemical features are avoided or 'synthesized out'; this could influence the design and development of future drugs. Further analysis of such features in hERG trafficking correctors may facilitate the design of a non-blocking corrector for trafficking defective hERG proteins in both congenital and acquired LQTS.
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