The hydrogen sulfide donor, GYY4137, exhibits anti‐atherosclerotic activity in high fat fed apolipoprotein E−/− mice
British Journal of Pharmacology2013Vol. 169(8), pp. 1795–1809
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Zhen Liu, Yi Han, Ling Li, Hui Lu, Guoliang Meng, Xiaozhen Li, Mohammed Shirhan, Meng Teng Peh, Liping Xie, Suming Zhou, Xiaowei Wang, Qi Chen, Weilu Dai, Choon‐Hong Tan, Shiyang Pan, Philip K. Moore, Yong Ji
Abstract
GYY4137 inhibits lipid accumulation induced by ox-LDL in RAW 264.7 cells. In vivo, GYY4137 decreased vascular inflammation and oxidative stress, improved endothelial function and reduced atherosclerotic plaque formation in apoE(-/-) mice.
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