Selective, potent blockade of the IRE1 and ATF6 pathways by 4‐phenylbutyric acid analogues
British Journal of Pharmacology2013Vol. 170(4), pp. 822–834
Citations Over TimeTop 19% of 2013 papers
Hui Zhang, Shotaro Nakajima, Hiroaki Kato, Liubao Gu, Tatsuya Yoshitomi, Kaoru Nagai, Hideyuki Shinmori, Susumu Kokubo, Masanori Kitamura
Abstract
The 4-PBA analogues 2-POAA-OMe, 2-POAA-NO2 and 2-NOAA strongly inhibited activation of the IRE1 and ATF6 pathways and downstream pathogenic targets, including NF-κB and Akt, in ER stress-exposed cells. These compounds may be useful for therapeutic intervention in ER stress-related pathological conditions.
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