Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre‐activation of AMPK‐dependent autophagy
British Journal of Pharmacology2014Vol. 171(13), pp. 3146–3157
Citations Over TimeTop 1% of 2014 papers
Teng Jiang, Jin‐Tai Yu, Xi‐Chen Zhu, Hui‐Fu Wang, Meng‐Shan Tan, Lei Cao, Qiao‐Quan Zhang, Li Gao, Jian‐Quan Shi, Yingdong Zhang, Lan Tan
Abstract
These results provide the first evidence that acute metformin preconditioning induces autophagy by activation of brain AMPK, which confers neuroprotection against subsequent cerebral ischaemia. This suggests that metformin, a well-known hypoglycaemic drug, may have a practical clinical use for stroke prevention.
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