Increased drug resistance is associated with reduced glucose levels and an enhanced glycolysis phenotype
British Journal of Pharmacology2014Vol. 171(13), pp. 3255–3267
Citations Over TimeTop 10% of 2014 papers
Bhaskar Bhattacharya, Sarah Löw, Chin Kok Soh, N Kamal Mustapa, Mounia Beloueche‐Babari, King Xin Koh, Jian Yun Loh, Richie Soong
Abstract
Hypoglycaemia increased resistance to cytotoxic agents, especially in tumour cells with a high dependence on glycolysis. Dual inhibition of the PI3K/mTOR pathway may be able to attenuate such hypoglycaemia-associated resistance.
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