Presynaptic adenosine A2A receptors dampen cannabinoid CB1 receptor‐mediated inhibition of corticostriatal glutamatergic transmission
British Journal of Pharmacology2014Vol. 172(4), pp. 1074–1086
Citations Over TimeTop 10% of 2014 papers
Samira G. Ferreira, Francisco Q. Gonçalves, Joana M. Marques, Ângelo R. Tomé, Ricardo J. Rodrigues, Isabel Nunes‐Correia, Catherine Ledent, Tibor Harkany, Laurent Venance, Rodrigo A. Cunha, Attila Köfalvi
Abstract
Activation of presynaptic A2A receptors dampened CB1 receptor-mediated inhibition of corticostriatal terminals. This constitutes a thus far unrecognized mechanism to modulate the potent CB1 receptor-mediated presynaptic inhibition, allowing frequency-dependent enhancement of synaptic efficacy at corticostriatal synapses.
Related Papers
- → Cannabinoids, endocannabinoids, and cancer(2011)153 cited
- The chemistry of endocannabinoids.(2006)
- → Role of Endocannabinoids and Cannabinoid CB1 Receptors in Alcohol‐Related Behaviors(2004)63 cited
- → Medicinal potential of anandamide as a representative endocannabinoid and its effect at the cellular level in skin(2023)3 cited
- → Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) in subcutaneous tissue and fasciae(2015)