Oestrogen inhibits BMP4‐induced BMP4 expression in cardiomyocytes: a potential mechanism of oestrogen‐mediated protection against cardiac hypertrophy
British Journal of Pharmacology2014Vol. 172(23), pp. 5586–5595
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Yuchun Wang, Xiao‐Lin Xiao, Na Li, Di Yang, Yue Xing, Rong Huo, Mingyu Liu, Yan‐Qiu Zhang, De‐Li Dong
Abstract
Oestrogen treatment inhibited BMP4-induced BMP4 expression in cardiomyocytes through stimulating oestrogen receptor-β and inhibiting JNK activation. Our results provide a novel mechanism underlying oestrogen-mediated protection against cardiac hypertrophy.
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