Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway
British Journal of Pharmacology2015Vol. 172(15), pp. 3929–3943
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Xin Xie, Yu Zhao, Chunyan Ma, Xiaoming Xu, Yan‐Qiu Zhang, Chenguang Wang, Jing Jin, Xin Shen, Jin‐Lai Gao, Na Li, Zhi‐Jie Sun, De‐Li Dong
Abstract
DMF but not its metabolite MMF induced necroptosis in colon cancer cells through a mechanism involving the depletion of GSH, an increase in ROS and activation of MAPKs.
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