Induction of the inflammatory regulator A20 by gibberellic acid in airway epithelial cells
British Journal of Pharmacology2015Vol. 173(4), pp. 778–789
Citations Over TimeTop 24% of 2015 papers
James Reihill, B Malcomson, Anne Kjørsvik Bertelsen, Sarah Cheung, Agnieszka Czerwiec, R. Barsden, J.S. Elborn, Horst Dürkop, Burkhard Hirsch, Madeleine Ennis, Catriona Kelly, Bettina Schock
Abstract
We showed that A20 induction by GA3 attenuates inflammation in airway epithelial cells, at least in part through its effect on NF-κB and IκBα. GA3 or gibberellin-derived derivatives could potentially be developed into anti-inflammatory drugs for the treatment of chronic inflammatory diseases associated with A20 dysfunction.
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