Early treatment with atorvastatin exerts parenchymal and vascular protective effects in experimental cerebral ischaemia
British Journal of Pharmacology2015Vol. 172(21), pp. 5188–5198
Citations Over TimeTop 14% of 2015 papers
Camille Potey, Thavarak Ouk, Olivier Pétrault, Maud Pétrault, Vincent Bérézowski, Julia Salleron, Régis Bordet, Sophie Gautier
Abstract
Acute atorvastatin provides global cerebral protection, but only at the higher dose of 20 mg·kg(-1) ·day(-1) ; this was associated with a reduction in inflammation in both vascular and parenchymal compartments. Our results suggest that atorvastatin could also be beneficial when administered early after stroke.
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