Natural and synthetic flavonoid modulation of TRPC5 channels
British Journal of Pharmacology2015Vol. 173(3), pp. 562–574
Citations Over TimeTop 14% of 2015 papers
Jacqueline Naylor, Aisling Minard, Hannah J. Gaunt, M. Samir Amer, Lesley Wilson, Marco Migliore, Sin Ying Cheung, Hussein N. Rubaiy, Nicola M. Blythe, Katie E. Musialowski, Melanie J. Ludlow, W. Douglas Evans, Ben L. Green, Hongjun Yang, Yun You, Jing Li, Colin W. G. Fishwick, Katsuhiko Muraki, David J. Beech, Robin S. Bon
Abstract
The data suggest that galangin (a natural product from the ginger family) is a TRPC5 inhibitor and that other natural and synthetic flavonoids contain antagonist or agonist capabilities at TRPC5 and closely related channels depending on the substitution patterns of both the chromone core and the phenyl ring.
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