Decursin enhances TRAIL‐induced apoptosis through oxidative stress mediated‐ endoplasmic reticulum stress signalling in non‐small cell lung cancers
British Journal of Pharmacology2015Vol. 173(6), pp. 1033–1044
Citations Over TimeTop 13% of 2015 papers
Jae Kwang Kim, Miyong Yun, Eun‐Ok Kim, Deok‐Beom Jung, Gunho Won, Bonglee Kim, Ji Hoon Jung, Sung‐Hoon Kim
Abstract
ROS generation by decursin selectively activated the PERK/ATF4 axis of the endoplasmic reticulum stress signalling pathway, leading to enhanced TRAIL sensitivity in TRAIL-resistant NSCLC cell lines, partly via up-regulation of DR5.
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