Role of COX‐2‐derived PGE2 on vascular stiffness and function in hypertension
British Journal of Pharmacology2016Vol. 173(9), pp. 1541–1555
Citations Over TimeTop 10% of 2016 papers
María Soledad Avendaño, Sonia Martínez‐Revelles, Andrea Aguado, Maylla Ronacher Simões, María González‐Amor, Roberto Palacios, Paloma Guillem‐Llobat, Dalton Valentim Vassallo, Luı́s Vila, Juan García‐Puig, Luis M. Beltrán, María J. Alonso, Victoria Cachofeiro, Mercedes Salaíces, Ana M. Briones
Abstract
COX-2 and EP1 receptors participate in the increased extracellular matrix deposition and vascular stiffness, the impaired vascular function and inflammation in hypertension. Targeting PGE2 receptors might have benefits in hypertension-associated vascular damage.
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