BN‐9, a chimeric peptide with mixed opioid and neuropeptide FF receptor agonistic properties, produces nontolerance‐forming antinociception in mice
British Journal of Pharmacology2016Vol. 173(11), pp. 1864–1880
Citations Over TimeTop 12% of 2016 papers
Ning Li, Zheng‐lan Han, Zilong Wang, Yan‐hong Xing, Yulong Sun, Xu‐Hui Li, Jingjing Song, Ting Zhang, Run Zhang, Mengna Zhang, Biao Xu, Quan Fang, Rui Wang
Abstract
BN-9 produced a robust, nontolerance-forming analgesia with limited inhibition of gastrointestinal transit. As BN-9 is able to activate both opioid and NPFF systems, this provides an interesting approach for the development of novel analgesics with minimal side effects.
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