The role of metformin and resveratrol in the prevention of hypoxia‐inducible factor 1α accumulation and fibrosis in hypoxic adipose tissue
British Journal of Pharmacology2016Vol. 173(12), pp. 2001–2015
Citations Over TimeTop 10% of 2016 papers
Xiaole Li, Jia Li, Lulu Wang, Aiyun Li, Zhixia Qiu, Lian‐Wen Qi, Junping Kou, Kang Liu, Baolin Liu, Fang Huang
Abstract
Hypoxia and fibrosis are early causes of adipose dysfunction in obesity. Both metformin and resveratrol effectively inhibited HIF-1α activation-induced fibrosis and inflammation in adipose tissue, although by different mechanisms.
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