A novel transgenic rabbit model with reduced repolarization reserve: long QT syndrome caused by a dominant‐negative mutation of the KCNE1 gene
British Journal of Pharmacology2016Vol. 173(12), pp. 2046–2061
Citations Over TimeTop 10% of 2016 papers
Péter Major, István Baczkó, László Hiripi, Katja E. Odening, Viktor Juhász, Zsófia Kohajda, András Horváth, György Seprényi, Mária Kovács, László Virág, Norbert Jost, János Prorok, Balázs Ördög, Zoltán Doleschall, Stanley Nattel, András Varró, Zsuzsanna Bösze
Abstract
We have created a novel transgenic LQT5 rabbit model with increased susceptibility to drug-induced arrhythmias that may represent a useful model for testing proarrhythmic potential and for investigations of the mechanisms underlying arrhythmias and sudden cardiac death due to repolarization disturbances.
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