Inhibition of PI3K promotes dilation of human small airways in a rho kinase‐dependent manner
British Journal of Pharmacology2016Vol. 173(18), pp. 2726–2738
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Cynthia Koziol‐White, Edwin Yoo, Gaoyuan Cao, Jie Zhang, Eleni Papanikolaou, Ivan Pushkarsky, Adam Andrews, Blanca E. Himes, Robert Damoiseaux, Stephen B. Liggett, Dino Di Carlo, Richard C. Kurten, Reynold A. Panettieri
Abstract
PI3Kδ inhibitors act as dilators of human small airways. Taken together, these findings provide alternative approaches to the clinical management of airway obstruction in asthma.
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