AP39, a mitochondria-targeting hydrogen sulfide (H2S) donor, protects against myocardial reperfusion injury independently of salvage kinase signalling
British Journal of Pharmacology2016Vol. 174(4), pp. 287–301
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Qutuba G. Karwi, Julia Bornbaum, Kerstin Boengler, Roberta Torregrossa, Matthew Whiteman, Mark E. Wood, Rainer Schulz, Gary F. Baxter
Abstract
AP39 protects against reperfusion injury independently of the cytosolic RISK pathway. This cardioprotective effect could be mediated by inhibiting PTP via a cyclophilin D-independent mechanism. Thus, selective delivery of H2 S to mitochondria may be therapeutically applicable for employing the cardioprotective utility of H2 S.
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