The inward rectifier current inhibitor PA‐6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models
British Journal of Pharmacology2017Vol. 174(15), pp. 2576–2590
Citations Over TimeTop 12% of 2017 papers
Yuan Ji, Rosanne Varkevisser, Dragan Opačić, Alexandre Bossu, Marion Kuiper, Jet D.M. Beekman, Sihyung Yang, Azinwi Phina Khan, Dobromir Dobrev, Niels Voigt, Michael Zhuo Wang, Sander Verheule, Marc A. Vos, Marcel A. G. van der Heyden
Abstract
PA-6 restored SR in goats with persistent AF and, in dogs with chronic AV block, prolonged QT intervals, without inducing TdP arrhythmias. Our results demonstrate cardiac safety and good anti-AF properties for PA-6.
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