PDE1A inhibition elicits cGMP‐dependent relaxation of rat mesenteric arteries
British Journal of Pharmacology2017Vol. 174(22), pp. 4186–4198
Citations Over Time
Makhala M. Khammy, Thomas Dalsgaard, Peter Hjørringgaard Larsen, Claus T. Christoffersen, Dorte Clausen, Lars K. Rasmussen, Lasse Folkersen, Morten Grunnet, Jan Kehler, Christian Aalkjær, Jacob Nielsen
Abstract
Pde1a is the dominant PDE1 isoform present in VSMCs, and relaxation mediated by PDE1A inhibition is predominantly driven by enhanced cGMP signalling. These results imply that isoform-selective PDE1 inhibitors are powerful investigative tools allowing examination of physiological and pathological roles of PDE1 isoforms.
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