Gα12 facilitates shortening in human airway smooth muscle by modulating phosphoinositide 3‐kinase‐mediated activation in a RhoA‐dependent manner
British Journal of Pharmacology2017Vol. 174(23), pp. 4383–4395
Citations Over TimeTop 18% of 2017 papers
Edwin Yoo, Gaoyuan Cao, Cynthia Koziol‐White, Christie A. Ojiaku, Krishna Sunder, Joseph A. Jude, James V. Michael, Hong Lam, Ivan Pushkarsky, Robert Damoiseaux, Dino Di Carlo, Kwangmi Ahn, Steven S. An, Raymond B. Penn, Reynold A. Panettieri
Abstract
Gα12 plays a crucial role in HASMC contraction via RhoA-dependent activation of the PI3K/ROCK axis. Inhibition of RhoA activation induces bronchodilation in hPCLS, and targeting Gα12 signaling may elucidate novel therapeutic targets in asthma. These findings provide alternative approaches to the clinical management of airway obstruction in asthma.
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