Towards functional selectivity for α6β3γ2 GABAA receptors: a series of novel pyrazoloquinolinones
British Journal of Pharmacology2017Vol. 175(3), pp. 419–428
Citations Over TimeTop 19% of 2017 papers
Marco Treven, David Chan Bodin Siebert, Raphael Holzinger, Konstantina Bampali, Jure Fabjan, Zdravko Varagić, Laurin Wimmer, Friederike Steudle, Petra Scholze, Michael Schnürch, Marko D. Mihovilovič, Margot Ernst
Abstract
These results constitute a major step towards a potential selective positive modulation of certain α6-containing GABAA receptors, which might be useful to elicit their physiological role. Furthermore, these studies pave the way towards insights into molecular principles that drive positive versus negative allosteric modulation of specific GABAA receptor isoforms.
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