Can non‐clinical repolarization assays predict the results of clinical thorough QT studies? Results from a research consortium
British Journal of Pharmacology2017Vol. 175(4), pp. 606–617
Citations Over TimeTop 10% of 2017 papers
Eun‐Jung Park, Gary A. Gintant, Daoqin Bi, Devi Kozeli, Syril Pettit, Jennifer Pierson, Matthew Skinner, James Willard, Todd Wisialowski, John Koerner, Jean‐Pierre Valentin
Abstract
The predictive value of hERG, APD and QTc assays varies, with drug concentrations strongly affecting translational performance. While useful in guiding preclinical candidates without clinical QT prolongation, hERG and QTc repolarization assays provide greater value compared with the APD assay.
Related Papers
- → Epinephrine-Induced QT Interval Prolongation: A Gene-Specific Paradoxical Response in Congenital Long QT Syndrome(2002)196 cited
- → Is Dispersion of Ventricular Repolarization Rate Dependent?(1997)53 cited
- → Global and local dispersion of ventricular repolarization: Endocardial monophasic action potential mapping in swine and humans by using an electro-anatomical mapping system(2002)11 cited
- → Antiepileptic rufinamide and QTc interval shortening in a patient with long QT syndrome: case report(2020)1 cited
- → Long QT Syndrome: Clinical and Genetic Diagnostic Complications(2021)1 cited