Selective late sodium current inhibitor GS‐458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia
British Journal of Pharmacology2018Vol. 175(12), pp. 2470–2482
Citations Over TimeTop 10% of 2018 papers
Alexandre Bossu, Marien J. C. Houtman, Veronique M.F. Meijborg, Rosanne Varkevisser, Henriëtte D.M. Beekman, Albert Dunnink, Jacques M.T. de Bakker, Névéna Mollova, Sridharan Rajamani, Luiz Belardinelli, Marcel A. G. van der Heyden, Marc A. Vos
Abstract
GS967 terminated all dofetilide-induced TdP without completely suppressing EADs and sEB in vitro and in vivo, respectively. The antiarrhythmic mode of action of GS967, through the reduction of spatial dispersion of repolarization, seems to predominantly impede the perpetuation of arrhythmic events into TdP rather than their initiating trigger.
Related Papers
- → Dofetilide‐Induced Long QT and Torsades de Pointes(2007)28 cited
- → Electrophysiologic Features of Torsades de Pointes:(1997)90 cited
- → Atrial-specific drug AVE0118 is free of torsades de pointes in anesthetized dogs with chronic complete atrioventricular block(2006)33 cited
- → The QT Interval and Drug-Associated Torsades de Pointes(1993)30 cited
- → Mechanisms of torsades de pointes(2022)