High‐fructose corn syrup consumption in adolescent rats causes bipolar‐like behavioural phenotype with hyperexcitability in hippocampal CA3‐CA1 synapses
British Journal of Pharmacology2018Vol. 175(24), pp. 4450–4463
Citations Over TimeTop 20% of 2018 papers
Barış Alten, Metin Yeşiltepe, Erva Bayraktar, Sadık Taşkın Taş, Ayşe Yeşim Göçmen, Canan Kurşungöz, Ana Martı́nez, Yıldırım Sara
Abstract
This study shows that HFCS consumption in adolescent rats led to a bipolar-like behavioural phenotype with neuronal hyperexcitability, which is known to be one of the earliest endophenotypic manifestations of bipolar disorder. Inhibition of GSK-3B with TDZD-8 attenuated hyperexcitability and restored HFCS-induced behavioural alterations.
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