A photoswitchable GABA receptor channel blocker
British Journal of Pharmacology2019Vol. 176(15), pp. 2661–2677
Citations Over TimeTop 18% of 2019 papers
Galyna Maleeva, Daniel Wutz, Karin Rustler, Alba Nin‐Hill, Carme Rovira, Elena Petukhova, Antoni Bautista-Barrufet, Alexandre M. J. Gomila, Petra Scholze, Franck Peiretti, Mercedes Alfonso‐Prieto, Burkhard Koenig, Pau Gorostiza, Pìotr Bregestovski
Abstract
Azo-NZ1 is a soluble light-driven Cl-channel blocker, which allows photo-modulation of the activity induced by anion-selective Cys-loop receptors. Azo-NZ1 is able to control GABAergic postsynaptic currents and provides new opportunities to study inhibitory neurotransmission using patterned illumination.
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