Potent, selective, and subunit‐dependent activation of TRPC5 channels by a xanthine derivative
British Journal of Pharmacology2019Vol. 176(20), pp. 3924–3938
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Aisling Minard, Claudia Bauer, Eulashini Chuntharpursat‐Bon, Isabelle B. Pickles, David J. Wright, Melanie J. Ludlow, Matthew Burnham, Stuart L. Warriner, David J. Beech, Katsuhiko Muraki, Robin S. Bon
Abstract
This study suggests the possibility for selective activation of TRPC5 channels by xanthine derivatives and supports the general principle that xanthine-based compounds can activate, potentiate, or inhibit these channels depending on subunit composition.
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