Fentanyl depression of respiration: Comparison with heroin and morphine
British Journal of Pharmacology2019Vol. 177(2), pp. 254–265
Citations Over TimeTop 10% of 2019 papers
Abstract
We propose that several factors (potency, rate of onset, lowered sensitivity to naloxone, and lowered cross tolerance to heroin) combine to make fentanyl more likely to cause opioid overdose deaths than other commonly abused opioids. Lipophilic antagonists such as diprenorphine may be better antidotes than naloxone to treat fentanyl overdose.
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