The hyperpolarization‐activated cyclic nucleotide‐gated 4 channel as a potential anti‐seizure drug target
British Journal of Pharmacology2020Vol. 177(16), pp. 3712–3729
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Qays Kharouf, A. Marie Phillips, Lauren E. Bleakley, Emma Morrisroe, Julia Oyrer, Linghan Jia, A. Ludwig, Liang Jin, Joseph A. Nicolazzo, Elisabetta Cerbai, María Novella Romanelli, Steven Petrou, Christopher A. Reid
Abstract
These data suggest the HCN4 channel as a potential pharmacologically relevant target for anti-seizure drugs that is likely to have a low side-effect liability in the CNS.
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