Effect of selective IK,ACh inhibition by XAF‐1407 in an equine model of tachypacing‐induced persistent atrial fibrillation
British Journal of Pharmacology2020Vol. 177(16), pp. 3778–3794
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Merle Friederike Fenner, Helena Carstensen, Sarah Dalgas Nissen, Eva Melis Hesselkilde, Christine Scott Lunddahl, Maja Adler Hess Jensen, Ameli Victoria Loft‐Andersen, Stefan M. Sattler, Pyotr G. Platonov, Saïd El-Haou, Claire Jackson, Raymond S. Tang, Robert W. Kirby, John W. Ford, Ulrich Schotten, J. Milnes, Ulrik S. Sørensen, Thomas Jespersen, Rikke Buhl
Abstract
XAF-1407 efficiently cardioverted sustained tachypacing-induced AF of short duration in horses without notable side effects. This supports IK,ACh inhibition as a potentially safe treatment of paroxysmal AF in horses, suggesting potential clinical value for other species including humans.
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