Sirtuin 3‐mediated deacetylation of acyl‐CoA synthetase family member 3 by protocatechuic acid attenuates non‐alcoholic fatty liver disease
British Journal of Pharmacology2020Vol. 177(18), pp. 4166–4180
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Ruimin Sun, Xiaohui Kang, Yan Zhao, Zhanyu Wang, Ruiwen Wang, Rong Fu, Yang Li, Yan Hu, Zhecheng Wang, Wen Shan, Junjun Zhou, Xiaofeng Tian, Jihong Yao
Abstract
SIRT3-mediated ACSF3 deacetylation is a novel molecular mechanism in NAFLD therapy and protocatechuic acid confers protection against high-fat diet- and palmitic acid-induced hepatic fatty acid metabolism disorder through the SIRT3/ACSF3 pathway.
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