The mechanism of non‐blocking inhibition of sodium channels revealed by conformation‐selective photolabeling
British Journal of Pharmacology2021Vol. 178(5), pp. 1200–1217
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M Földi, Krisztina Pesti, Katalin Zboray, Adam V. Toth, Tamás Hegedűs, András Málnási‐Csizmadia, Péter Lukács, Árpád Mike
Abstract
Our results identify riluzole as the prototype of this new class of sodium channel inhibitors. Drugs of this class are expected to selectively prevent hyperexcitability, while having minimal effect on cells firing at a normal rate from a normal resting potential.
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