Acinar cell NLRP3 inflammasome and gasdermin D (GSDMD) activation mediates pyroptosis and systemic inflammation in acute pancreatitis
British Journal of Pharmacology2021Vol. 178(17), pp. 3533–3552
Citations Over TimeTop 10% of 2021 papers
Lin Gao, Xiaowu Dong, Weijuan Gong, Wei Huang, Jing Xue, Qingtian Zhu, Nan Ma, Weiwei Chen, Xianghui Fu, Xiang Gao, Zhaoyu Lin, Yanbing Ding, Juanjuan Shi, Zhihui Tong, Tingting Liu, Rajarshi Mukherjee, Robert Sutton, Guotao Lu, Weiqin Li
Abstract
This work demonstrates a critical role for NLRP3 inflammasome and GSDMD activation-mediated pyroptosis in acinar cells, linking pancreatic necrosis and systemic inflammation in AP. Targeting pyroptosis signalling pathways holds promise for specific AP therapy.
Related Papers
- → PANoptosis: A Cell Death Characterized by Pyroptosis, Apoptosis, and Necroptosis(2023)157 cited
- → Caspase-Linked Programmed Cell Death in Prostate Cancer: From Apoptosis, Necroptosis, and Pyroptosis to PANoptosis(2023)31 cited
- → [The molecular mechanisms and the functions of new types of regulated cell death including necroptosis, ferroptosis, and pyroptosis.](2019)3 cited
- → Programmed Cell Death in Prostate Cancer: From Apoptosis, Necroptosis, and Pyroptosis to PANoptosis(2023)5 cited
- → Overview of necroptosis and pyroptosis signaling pathways(2020)