Quantitative prediction of P‐glycoprotein‐mediated drug–drug interactions and intestinal absorption using humanized mice
British Journal of Pharmacology2021Vol. 178(21), pp. 4335–4351
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Taiji Miyake, Haruka Tsutsui, Kenta Haraya, Tatsuhiko Tachibana, Kayoko Morimoto, Shoko Takehara, Miho Ayabe, Kaoru Kobayashi, Yasuhiro Kazuki
Abstract
These results suggest that P-gp-mediated DDI and non-linear absorption can be predicted using hMDR1-MAC mice. These mice are a useful in vivo tool for quantitatively predicting P-gp-mediated disposition in drug discovery and development.
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