The STING antagonist H‐151 ameliorates psoriasis via suppression of STING/NF‐κB‐mediated inflammation
British Journal of Pharmacology2021Vol. 178(24), pp. 4907–4922
Citations Over TimeTop 10% of 2021 papers
Yanhong Pan, Yanping You, Li Sun, Qibang Sui, Liu Liu, Haoliang Yuan, Caiping Chen, Jun Liu, Xiaoan Wen, Liang Dai, Hongbin Sun
Abstract
H-151 displayed anti-inflammatory activity in both keratinocytes and immune cells, and decreased the severity of psoriatic response in vivo. Inhibition of STING signalling pathway may represent a novel therapeutic approach to psoriasis and related complications.
Related Papers
- → Prolonged activation of innate immune pathways by a polyvalent STING agonist(2021)288 cited
- → STING inhibitors target the cyclic dinucleotide binding pocket(2021)231 cited
- → Regulating STING in health and disease(2017)93 cited
- → In vitro STING Activation with the cGAMP-STINGΔTM Signaling Complex(2021)3 cited
- The new progress of Imiquimod-induced psoriasis mechanism(2013)