Targeting the OXE receptor with a selective antagonist inhibits allergen‐induced pulmonary inflammation in non‐human primates
British Journal of Pharmacology2021Vol. 179(2), pp. 322–336
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Chantal Cossette, Lisa A. Miller, Qiuji Ye, Shishir Chourey, Chintam Nagendra Reddy, Joshua Rokach, William S. Powell
Abstract
This study provides the first evidence that 5-oxo-ETE may play an important role in inducing allergen-induced pulmonary inflammation and could also be involved in regulating MUC5AC in goblet cells. OXE receptor antagonists such as S-Y048 may useful therapeutic agents in asthma and other eosinophilic as well as neutrophilic diseases.
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