A novel peptide inhibitor of Dll4‐Notch1 signalling and its pro‐angiogenic functions
British Journal of Pharmacology2021Vol. 179(8), pp. 1716–1731
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Guofu Zhu, Ying Lin, Tandi Ge, Shekhar Singh, Hao Liu, Linlin Fan, Shumin Wang, Jordan Rhen, Dongyang Jiang, Yuyan Lyu, Yiheng Yin, Xiankai Li, Danielle S. W. Benoit, Weiming Li, Yawei Xu, Jinjiang Pang
Abstract
We synthesized and investigated the biological actions of TAT-ANK peptide, a new inhibitor of Notch signalling. This peptide will be of significant interest to research on Dll4-Notch1 signalling and to clinicians carrying out clinical trials using Notch signalling inhibitors. Furthermore, our findings will have important conceptual and therapeutic implications for angiogenesis-related diseases.
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