Regenerating islet‐derived protein 3 gamma (Reg3g) ameliorates tacrolimus‐induced pancreatic β‐cell dysfunction in mice by restoring mitochondrial function
British Journal of Pharmacology2022Vol. 179(12), pp. 3078–3095
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Senlin Li, Hong Zhou, Mengyuan Xie, Zijun Zhang, Jing Gou, Jian Yang, Cheng Tian, Kun Ma, Cong‐Yi Wang, Yi Lü, Qing Li, Wen Peng, Ming Xiang
Abstract
Reg3g can significantly ameliorate tacrolimus-induced β-cell dysfunction by restoring mitochondrial function in a pSTAT3(Ser727)-dependent manner. Our observations identify a novel Reg3g-mediated mechanism that is involved in tacrolimus-induced NODM and establish the novel role of Reg3g in reversing tacrolimus-induced β-cell dysfunction.
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