The VRAC blocker DCPIB directly gates the BK channels and increases intracellular Ca2+ in melanoma and pancreatic duct adenocarcinoma cell lines
British Journal of Pharmacology2022Vol. 179(13), pp. 3452–3469
Citations Over TimeTop 16% of 2022 papers
Paolo Zuccolini, Loretta Ferrera, Alessia Remigante, Cristiana Picco, Raffaella Barbieri, Sara Bertelli, Óscar Morán, Paola Gavazzo, Michael Pusch
Abstract
DCPIB directly targeted BK channels and, also, acutely increased intracellular Ca2+ . Our findings extend the list of DCPIB effects that should be taken into consideration for future development of DCPIB-based modulators of ion channels and other membrane proteins.
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