Reelin cells and sex‐dependent synaptopathology in autism following postnatal immune activation
British Journal of Pharmacology2022Vol. 179(17), pp. 4400–4422
Citations Over TimeTop 11% of 2022 papers
Maryam Ardalan, Tetyana Chumak, Alexandra Quist, Eva C. Hermans, Ali H. Rafati, Giacomo Gravina, Seyedeh Marziyeh Jabbari Shiadeh, Pernilla Svedin, Setareh Alabaf, Brian Hansen, Gregers Wegener, Lars Westberg, Carina Mallard
Abstract
The study provides new insights into sex-dependent mechanisms that may underlie ASD-like behaviour in males following postnatal immune activation. We identify GABAergic interneurons as core components of dysmaturation of excitatory synapses in the hippocampus following postnatal infection and provide cellular and molecular substrates for the MRI findings with translational value.
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