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Paediatric sepsis survivors are resistant to sepsis‐induced long‐term immune dysfunction
British Journal of Pharmacology2023Vol. 181(8), pp. 1308–1323
David F. Cólon, Carlos W. Wanderley, Walter Miguel Turato, Vanessa F. Borges, Marcelo Franchin, Fernanda V. S. Castanheira, Daniele Nascimento, Douglas da Silva Prado, Mikhael Haruo Fernandes de Lima, Leila Costa Volpon, Silvia K. Kavaguti, Ana Paula de Carvalho Panzeri Carlotti, Fábio Carmona, Bernardo S. Franklin, Thiago M. Cunha, José C. Alves‐Filho, Fernando Q. Cunha
Abstract
These findings demonstrate a crucial and age-dependent role for IL-33 in post-sepsis immunosuppression. Thus, a better understanding of this process may lead to differential treatments for adult and paediatric sepsis.
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