The mitochondrial calcium uniporter inhibitor Ru265 increases neuronal excitability and reduces neurotransmission via off‐target effects
British Journal of Pharmacology2024Vol. 181(18), pp. 3503–3526
Citations Over TimeTop 11% of 2024 papers
Peng Xu, Sarpras Swain, Robyn J. Novorolsky, Esperanza Garcı́a, Zhouyang Huang, Terrance P. Snutch, Justin J. Wilson, George S. Robertson, Robert Renden
Abstract
Our findings provide a mechanistic explanation for the pro-convulsant effects of Ru265 and suggest counter screening assays based on the measurement of P/Q and KCNQ channel currents to identify safe MCU inhibitors.
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