Smooth muscle cell Piezo1 is essential for phenotypic switch and neointimal hyperplasia
British Journal of Pharmacology2025Vol. 182(9), pp. 2031–2048
Citations Over TimeTop 10% of 2025 papers
F. Zhang, Jie Tang, Ying Lai, Shiqi Mo, Zhuomiao Lin, Qingqing Lei, Cong‐Cong Han, Andong Zhou, Xiao‐Fei Lv, Cheng Wang, Jing‐Song Ou, Jia‐Guo Zhou, Rui‐Ping Pang
Abstract
These findings demonstrate a critical role of mechanosensitive Piezo1 channel in neointimal hyperplasia via modulating VSMC phenotype. Piezo1 channels may represent a novel therapeutic target for maladaptive vascular remodelling and occlusive vascular diseases.
Related Papers
- → Piezo1, a mechanically activated ion channel, is required for vascular development in mice(2014)874 cited
- → Ion Permeation and Mechanotransduction Mechanisms of Mechanosensitive Piezo Channels(2016)236 cited
- → Roles of mechanosensitive channel Piezo1/2 proteins in skeleton and other tissues(2021)192 cited
- → The role of mechanosensitive Piezo1 channel in diseases(2022)26 cited
- → Inflammatory Cytokine Il-1α Up-Regulates Piezo1 and Hyper-Sensitizes Chondrocytes to Compression(2016)