Mapping of TLR5 and TLR7 in central and distal human airways and identification of reduced TLR expression in severe asthma
Clinical & Experimental Allergy2013Vol. 44(2), pp. 184–196
Citations Over TimeTop 10% of 2013 papers
Medya Shikhagaie, Cecilia Andersson, M. Mori, Inge Kortekaas Krohn, Anders Bergqvist, Ronald Dahl, Eva Ekblad, Hans Jürgen Hoffmann, Leif Bjermer, Jonas S. Erjefält
Abstract
Our results reveal broad expression patterns of TLR5 and TLR7 in the lung and that the expression is decreased in severe asthma. Hence, severe asthmatics may suffer from insufficient TLR signalling during viral or bacterial infections leading to poor and impaired defence mechanisms.
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