Allopurinol hypersensitivity is primarily mediated by dose-dependent oxypurinol-specific T cell response
Clinical & Experimental Allergy2013Vol. 43(11), pp. 1246–1255
Citations Over TimeTop 10% of 2013 papers
James Yun, Jonas Mattsson, Klara Schnyder, Stefano Fontana, Carlo R. Largiadèr, Werner J. Pichler, Daniel Yerly
Abstract
This study establishes the important synergistic role of drug concentration and HLA-B*58:01 allele in the allopurinol or oxypurinol-specific T cell responses. Despite the prevailing dogma that Type B adverse drug reactions are dose independent, allopurinol hypersensitivity is primarily driven by oxypurinol-specific T cell response in a dose-dependent manner, particular in the presence of HLA-B*58:01 allele.
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