Childhood exposure to ambient polycyclic aromatic hydrocarbons is linked to epigenetic modifications and impaired systemic immunity in T cells
Clinical & Experimental Allergy2014Vol. 45(1), pp. 238–248
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Kinjal Hew, Annett Walker, Arjun H. Kohli, Marco Garcia, Ali Syed, Cameron McDonald-Hyman, Elizabeth M. Noth, Jennifer Mann, Boriana Pratt, John R. Balmes, S. Katharine Hammond, Ellen A. Eisen, Kari C. Nadeau
Abstract
Collectively, these results demonstrate that increased ambient PAH exposure is associated with impaired systemic immunity and epigenetic modifications in a key locus involved in atopy: FOXP3, with a higher impact on atopic children. The results suggest that increased atopic clinical symptoms in children could be linked to increased PAH exposure in air pollution.
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