Long‐term evaluation of mesenchymal stem cell therapy in a feline model of chronic allergic asthma
Clinical & Experimental Allergy2014Vol. 44(12), pp. 1546–1557
Citations Over TimeTop 10% of 2014 papers
Julie E. Trzil, Isabelle Masseau, Teckla L. Webb, Chee‐Hoon Chang, John R. Dodam, Leah A. Cohn, H. Liu, Jessica M. Quimby, Steven Dow, Carol R. Reinero
Abstract
When administered after development of chronic allergic feline asthma, MSCs failed to reduce airway inflammation and AHR. However, repeated administration of MSCs at the start of study did reduce computed tomographic measures of airway remodelling by month 8, although the effect was not sustained at month 12. Further study of MSC therapy including repeated MSC administration is warranted to assess impact on remodelling in chronic asthma.
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