ST13 polymorphisms and their effect on exacerbations in steroid‐treated asthmatic children and young adults
Clinical & Experimental Allergy2015Vol. 45(6), pp. 1051–1059
Citations Over TimeTop 11% of 2015 papers
Susanne J. H. Vijverberg, Ellen S. Koster, Roger Tavendale, Maarten Leusink, Leo Koenderman, J. A. M. Raaijmakers, Dirkje S. Postma, Gerard H. Koppelman, Steve Turner, Somnath Mukhopadhyay, S. M. Tse, Kelan G. Tantisira, Daniel B. Hawcutt, Ben Francis, Munir Pirmohamed, Maria Pino‐Yanes, Celeste Eng, Esteban G. Burchard, C. N. A. Palmer, Anke H. Maitland‐van der Zee
Abstract
A novel susceptibility gene, ST13, coding for a cochaperone of the glucocorticoid receptor, is associated with exacerbations in asthmatic children and young adults despite their ICS use. Genetic variation in the glucocorticoid signalling pathway may contribute to the interindividual variability in clinical response to ICS treatment in children and young adults.
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