Naturally occurring tolerance acquisition to foods in previously allergic children is characterized by antigen specificity and associated with increased subsets of regulatory T cells
Clinical & Experimental Allergy2015Vol. 45(11), pp. 1663–1672
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Nida Qamar, Anna Fishbein, Kris Erickson, Miao Cai, Christine Szychlinski, Paul Bryce, Robert P. Schleimer, Ramsay Fuleihan, Arushi Singh
Abstract
The increased CD3+CD4+CD25+CD127lo cells at baseline and upon stimulation and increased induction of IL-10-producing cells of several types, including Tr1 cells, from naturally tolerant patients suggests an important role for regulatory T cell subsets in the acquisition of natural tolerance.
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