Role of local eosinophilopoietic processes in the development of airway eosinophilia in prednisone‐dependent severe asthma
Clinical & Experimental Allergy2015Vol. 46(6), pp. 793–802
Citations Over TimeTop 10% of 2015 papers
Roma Sehmi, Steven G. Smith, Melanie Kjarsgaard, Katherine Radford, Louis‐Philippe Boulet, Catherine Lemière, Charlene M. Prazma, Héctor Ortega, James G. Martin, P. Nair
Abstract
Patients with severe eosinophilic asthma have an exaggerated eosinophilopoeitic process in their airways. Treatment with 100 mg subcutaneous mepolizumab significantly attenuated systemic differentiation of eosinophils, but did not suppress local airway eosinophil differentiation to mature cells. Targeting IL-5-driven eosinophil differentiation locally within the lung maybe of relevance for optimal control of airway eosinophilia and asthma.
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